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Shifting the paradigm; Mapping The Pathogenesis of Endometriosis through an Integrative lens with Tanya Borowski
The paradigm shift we're witnessing isn't about adding the next “endo” formulated supplement to conventional care – it's about completely reimagining pathogenesis through an integrative understanding that honors the intricate web of biological, environmental, and psychosocial factors that converge to create this complex syndrome.
Through this new lens, we see endometriosis not as a hormonally driven gynecological condition, but as the outcome of multiple interconnected system failures: compromised detoxification pathways creating hormonal chaos, dysbiotic microbiomes and infectious burdens triggering systemic inflammation, unresolved trauma dysregulating the nervous system, and environmental toxicants disrupting cellular communication. Each factor doesn't work in isolation – they create cascading loops of dysfunction that amplify each other, explaining why conventional single-target approaches so often fail.
In this foundational session, we'll deconstruct the old paradigm and reconstruct a comprehensive pathogenesis map that explains not just how endometriosis develops, but why it persists, why it varies so dramatically between women, and most importantly – where and how we can intervene.
Learning outcomes:
The role of the microbiomes, immune & nervous system
Understanding the inflammatory-angiogenesis-hormone loop
Progesterone resistance & its role in endo
Genetic & epigenetic factors
Indicated interventions based on sex hormone pathology
Evidence based & clinically proven nutritional & herbal medicine interventions.
Hormonal medical management: efficacy & how to safely support symptoms alongside the hormonal IUD
Endometriosis through the lens of Immune dysfunction with Tanya Borowski
In this lecture Tanya explores how aberrant immune responses—including altered macrophage function, compromised natural killer cell activity, dysregulated cytokine networks, and impaired immune surveillance—create a permissive environment for ectopic endometrial tissue survival and proliferation. We will examine the intricate relationship between hormonal influences and immune dysfunction, investigate how chronic inflammation perpetuates the disease process, and discuss the critical role of the endocannabinoid system in modulating both endocrine & immune responses together with pain pathways in endometriosis.
Learning Outcomes:
Analyze immune system dysfunction in endometriosis
Examine the role of chronic inflammation in endometriosis pathogenesis,
Understand endocannabinoid system dysregulation in endometriosis, including its impact on pain processing, inflammation resolution, hormonal interactions, and the gut-brain-pelvis connection.
Integrate knowledge of immune, hormonal, and endocannabinoid system interactions
The Hidden Trigger: LPS, Dysbiosis and the Microbiome's Role in Endometriosis Inflammation with Tracey Randell; Nutritional Therapist, IFM Certified Practicioner
One of the most groundbreaking discoveries in endometriosis research has been the recognition that this condition isn't just about rogue endometrial tissue – it's about systemic inflammation driven by microbial imbalances. In this session, we explore the intricate relationship between dysbiosis and endometriosis, decode the mechanisms by which LPS perpetuates chronic inflammation, and most importantly, discover evidence-based strategies to manipulate and restore healthy microbiome balance
Learning outcomes:
The LPS theory and its role as a primary inflammatory driver in endometriosis
Identify the four key microbiome environments (gut, vaginal, oral, and endometrial) and assess how dysbiosis in each cavity contributes to endometriosis pathogenesis and symptom severity
Integrate microbiome-focused interventions into comprehensive endometriosis treatment plans
How Nervous System Dysregulation and Trauma Fuel the Endometriosis Fire with Rachel Jessey; Nutritionist, Naturopath & Quantum Biologist Practioner
The most revolutionary understanding in endometriosis care may be this: the nervous system doesn't just feel the pain – it creates and perpetuates it. Far beyond the traditional view of endometriosis as a purely gynecological condition, we now recognize that nervous system dysregulation and unresolved trauma are fundamental drivers of the inflammatory cascade, pain amplification, and treatment resistance seen in so many women. When the nervous system becomes trapped in chronic fight-or-flight states – whether from medical trauma, sexual trauma, or the relentless stress of living with dismissed symptoms – it creates a neuroinflammatory environment that feeds endometriosis lesions, sensitizes pain pathways, and hijacks the body's natural healing mechanisms.
Learning outcomes:
This understanding opens extraordinary therapeutic possibilities that go far beyond prescribing adaptogens or beta-blockers. We're talking about interventions that work with the body's innate wisdom to restore nervous system balance, release trapped trauma, and rewire pain pathways.
Expert Panel Q&A:
Emma Beswick Emma is the founder of the leading nutrigenomic company Lifecode Gx. The field of nutrigenomics plays a vital role in women's health, particularly in understanding endometriosis syndrome. Her expertise spans the biotransformation of hormones, receptor health and viability, as well as immune system and inflammatory responses.
Having Emma at this event and on the expert panel provides delegates with yet another crucial piece of the endometriosis puzzle - insights that go beyond the lesions themselves. Her unique perspective on the genetic and nutritional factors underlying this complex condition offers attendees valuable knowledge that extends far beyond traditional treatment approaches.
Tracey Randell Tracey is a Nutritional Therapist and fully certified IFM (Institute for Functional Medicine) practitioner with over 15 years of experience. Her specialist interest lies in the gut and microbiomes - encompassing not just the gastrointestinal system but the reproductive microbiomes as well.
Tracey provides crucial and current information and knowledge that is essential for understanding the heterogeneous presentation of endometriosis. Her expertise in the interconnected relationship between gut health and reproductive wellness offers delegates valuable insights into the complex microbial factors that influence women's health conditions. Rachel Jessey Rachel is a Naturopath and Quantum Biology Practitioner with specialized expertise in the nervous system's complex role in endometriosis management. Her work in supporting and understanding the intricacies of the nervous system and the part it plays within the ongoing pain experienced with endometriosis provides truly exceptional insights for practitioners. Rachel's unique approach bridges traditional naturopathic principles with cutting-edge quantum biology, offering delegates a deeper understanding of how nervous system dysfunction contributes to endometriosis symptoms.Her expertise is particularly valuable for practitioners seeking to address the neurological components of endometriosis pain and develop more comprehensive treatment approaches.
Richa Puri - Richa brings a unique background to our expert panel as a prescribing pharmacist, nutritional therapist, and fully certified IFM practitioner with a specialist interest in women's health. Richa works with women across all life stages and encounters endometriosis frequently in her practice - having her input on our expert panel provides invaluable insights.
Charlotte Hunter - Charlotte is a Nutritional Therapist currently pursuing her second MSc - seriously! in Nutritional Medicine at The University of Surrey, who brings both professional expertise and deeply personal insight to women's health. A mother of two wonderful sons, Charlotte's journey through endometriosis, PCOS, infertility, adenomyosis, and cervical complications—culminating in a total hysterectomy at 44—has transformed her into a passionate advocate for women navigating similar challenges. Her unique blend of clinical knowledge and lived experience makes her an invaluable voice on our expert panel.
Jo Majithia - Jo is a Registered Nutritional Therapist and has been in continual practice since 2003. Jo heads up the clinical education team at Regenerus Laboratories, and will be on hand to discuss with delegates the utilaztion of testing options for Vaginal Microbiome, Urinary Infections, which ties in beautifully with Tracey Randell’s presentation.
Dawn Waldron - Following her own cancer diagnosis in 1997, Dawn knew instinctively that she would need ‘more than medicine’ to stand a chance of seeing her daughter (now 30!) grow up but there was no one to turn to. Fast forward through decades of lived experience of both cancer and severe endometriosis resulting in a radical hysterectomy at age 39, dedicated clinical work as a NT, self-directed learning, continuing study, copious research, academic lecturing and public speaking. Having Dawn on the Expert panel, is truly an honour.